Objective: To probe into the effects of common antiepileptic drugs combined with vitamin B12 and folic acid on serum homocysteine (Hcy) and blood ammonia levels in children with epilepsy. Methods: A total of 270 children with epilepsy admitted into Hebei General Hospital from Jan. 2015 to Feb. 2018 were selected. According to different oral antiepileptic drugs (AEDs)

all patients were divided into 65 cases in the single oxcarbazepine group

65 cases in the single sodium valproate group

70 cases in the oxcarbazepine combined with vitamin B12 / folic acid group

and 70 cases in the sodium valproate combined with vitamin B12 / folic acid group. After 3 months of intervention

serum Hcy

blood ammonia

vitamin B12 and folic acid levels were detected. The quality of life

anxiety

depression and negative emotions of the children before and after treatment were observed

and the recurrence rate and recurrence time were counted in the follow-up for 1 year. Results: After treatment

the total effective rates of oxcarbazepine combined with vitamin B12 / folic acid group and sodium valproate combined with vitamin B12 / folic acid group were respectively 94.3% and 92.9%

higher than those of the single oxcarbazepine group and single sodium valproate group (P <0.05). After treatment

the proportions of high serum Hcy and high blood ammonia in oxcarbazepine combined with vitamin B12 / folic acid group and sodium valproate combined with vitamin B12 / folic acid group were lower than those in single oxcarbazepine group and single sodium valproate group (P<0.05). There were no significant differences in Hcy and blood ammonia levels between the oxcarbazepine combined with vitamin B12 / folic acid group and sodium valproate combined with vitamin B12 / folic acid group

and between the single oxcarbazepine group and single sodium valproate group (P>0.05). Groups of eeg before and after the treatment the delta

beta

theta

ɑ wave spectrum proportion within the group

group comparison between no statistical significance (P>0.05). After treatment

QOLIE-31 scores in observation group 1 and observation group 2 were higher than those in oxapine group and valproate group

and HAMD and HAMA scores were lower than those in oxapine group and valproate group (P<0.05). Follow-up after treatment for one year showed that the recurrence rate and time of recurrence in group 1 and group 2 were lower than those in oxacepine group and valproate group (P<0.05). Conclusion: Antiepileptic drugs combined with vitamin B12 and folic acid supplementation can reduce the blood Hcy and blood ammonia content in children with epilepsy

improve the treatment effect

improve the eeg status

improve the quality of life

reduce the psychological adverse mood

and do not increase the incidence of adverse reactions.